What is PrEP and what does it do?

What is PrEP ?

PrEP is a daily pill taken by people who are HIV negative to prevent HIV infection.
PrEP stands for Pre-Exposure Prophylaxis.

Pre – before
Exposure – coming into contact with HIV
Prophylaxis – a medicine to prevent infection

What’s the difference between PrEP, PEP and ARVs?

PrEP is taken by HIV negative people in advance BEFORE sex to prevent HIV.
PEP is taken by HIV negative people as an emergency treatment AFTER high risk exposure to HIV.
ARVs are medication taken by people who are HIV positive to stay healthy.

What is the standard PrEP dosage?

1 pill per day

How much does it cost?

PrEP is supplied free by Engage Men’s Health to gay, bisexual and other men who have sex with men (MSM).

How well does it work?

HIV-negative people who take PrEP every day can lower their risk of HIV by 99%.

Who should take PrEP?

Only people who are HIV negative, especially those at high risk of HIV infection. This includes people who have multiple sex partners and inconsistent (or no) condom use, men who have sex with men, those in relationships with HIV positive partners, recreational drug users who engage in chemsex, injecting drug users and sex workers.

For how long do I take it?

You need to take PrEP for as long as you feel you will need HIV prevention. You can stop taking it when you don’t need it anymore. This depends on your sexual behaviour. It is important to remember that if you stop taking PrEP you are not protected from HIV. You can start PrEP again in future if you want to go back on it. It is advisable to let your healthcare worker know when you decide to stop and to speak to them if a long period has passed since you stopped and want to start again.

What does PrEP prevent?

PrEP ONLY prevents HIV infection, and not other sexually transmitted infections (STIs).

What about using condoms?

Daily use of PrEP will protect you from HIV infection, even without condoms. The use of condoms and water-based lube is, however, still recommended as this will also help protect you from other sexually transmitted infections (STIs).

What are the side effects?
Some people may experience mild side effects when they start PrEP.
• Nausea
• Headache
• Tiredness
• Diarrhoea
• Depression
• Unusual dreams
• Vomiting
• Rash
• Problems sleeping
• Changes in appetite
In most people, these side effects go away after a few weeks.

How do I start PrEP?
Make an appointment at one of our sites in Johannesburg, Port Elizabeth or East London or see one of our outreach teams:

• We will give you a rapid HIV test.
• If the result is negative, you’ll be given PrEP for a month.
• Blood will also be drawn from your arm and will be sent to the lab. The lab will:
+ double check for HIV again
+ check for kidney function
• Return after a month.
• If blood results from the lab show you are HIV positive or that your kidney function is bad: you stop PrEP immediately.
• If blood results from the lab confirm you are HIV negative and kidney function is good: you will receive a 3 month supply of PrEP.
• Your next appointment for blood tests and PrEP collection will be in 3 months.

How long before it starts to work?
You need to take PrEP every day it for at least 7 days before it will protect you when it comes to anal sex. (A woman or transgender man who has vaginal sex must take PrEP daily for 21 days for it to work.)

What happens if I forget to take it?

If you forget to take your PrEP pill on a certain day, take it as soon as you remember (but don’t take it twice in a day if you forgot to take it yesterday). If you take PrEP daily, you will become more than 90% protected from HIV. Very occasionally missing a day shouldn’t have a major impact but the more you miss taking it daily the less effective it becomes. If you stop completely, you will no longer be protected at all.

Any other tips for taking PrEP?

* Drink plenty of water while on PrEP to keep kidney function good
* Set an alarm to remind you to take PrEP
* Talk to your clinician about side effects
* If you forget to take PrEP, take it in the moment you remember it.

Who do I contact to get free PrEP?

If you live in the Johannesburg metro, Nelson Mandela Bay or Buffalo City areas call or WhatsApp / Engage Men’s Health on: 082 607 1686. (If you live in other areas, you can also contact us and we will try to refer you to another service closer to you.)